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F18 Multifunctional Synthesizer

The PET-IFB-FN multifunctional automated synthesizer is computer-controlled

Category:

Radiopharmaceutical synthesizer

Key words:

synthesizer

equipped

multifunctional


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Product description

PET IFB Fn multifunctional synthesizer

The PET-IFB-FN multifunctional automated synthesizer is computer-controlled and equipped with semi preparative HPLC and SPE for rapid separation and purification. It can also be concentrated and solvent removed online for clinical and scientific preparation of 18F radiolabeled drugs. It can also be used for the preparation of radiolabeled drugs such as 64Cu, 68Ga, 90Y, 99mTc, 124I, 177Lu, 211At, 225Ac, etc. Equipped with online semi preparative HPLC, it can prepare a large number of drugs and synthesize various scientific drugs with a simple and easy-to-use user interface. The drag and drop interface allows users to freely edit the new drug interface according to their needs.

 

System features

Double reaction tube

Equipped with semi preparative HPLC

Full wavelength ultraviolet detector

Online concentration and purification

Highly flexible operating modes (fully automatic, semi-automatic, and manual)

Powerful research programming capabilities and hardware support

Extremely high reliability

High synthesis efficiency (18F-FDG uncorrected synthesis efficiency ⩾ 70%)

Compliant with GMP requirements

 

TECHNICAL INDEX

The complete set of equipment includes:

1 synthesizer

1 controller

1 control computer and 1 set of control software

Appearance dimensions:

Synthesizer: 350x510x400mm (height x width x depth) (placed in a hot room)

Controller: 220x355x400mm (height x width x depth) (placed outdoors)

HPLC (pump and UV): built-in

Temperature control system:

Heating rate: 25 ℃~120 ℃, time 10s ± 2s

Temperature accuracy: error<3%

Cooling rate: 120 ℃~50 ℃, time 25st2s

Temperature accuracy: error<3%

Interlocking: Hardware and Software

Reaction system:

Reaction system: closed type

Number of heaters: 3

Number of reactors: 3

Radioactive detector:

Type of radioactive detector: GM counter tube or semiconductor

Number of radioactive detectors: 4 or more

Detection range: 1mci~3C

Detection accuracy: error<10%

Typical production varieties and yields (compliant with GMP):

18F-FDG  FDG uncorrected synthesis efficiency: ⩾ 70%

FDG radiochemical purity: ⩾ 99.0%

FDG synthesis time: ≤ 25min

18F-PSMA, 18F-NaF, 18F-AV45, 18F-FET, 18F-FDDNP, 18F-FETNIM, 18F-FES, 18F-FLT, 18F-FECH, 18F-SFB, 18F-Ortreotide, 18F-MPPF, 18F-FP-B-CIT, 18F-FMISO, 64Cu, 68Ga, 90Y, 99mTc, 124I, 177Lu, 211At, 225Ac and other labeled drugs

Control system:

Software interface type: TCP/IP

Communication cable: Ethernet cable

Remote control: Yes

Mobile control: Yes

Computer: Laptop or desktop computer, Windows operating system. Drag and drop interface editing, users can freely edit the new drug interface according to their needs

 

Working conditions

Environmental temperature:

The ambient temperature ranges from 15 ℃ to 35 ℃; Relative humidity ≤ 85%; The air pressure is not limited.

Gas source requirements:

Nitrogen purity: 299.9%;

Compressed air: pressure ≥ 0.6-0.8 MPa, with a 0.6 cubic meter gas storage tank, a 12mm diameter air pipe is required from the gas tank to the equipment, and pure air without oil or water.

Hot room requirements:

The internal net size can accommodate the synthesizer, with 300mm left in the front and rear directions, 200mm left in the up and down directions, and 200mm left and right directions for maintenance or expansion space.

Power Supply:

There is a 220V 10A three core power socket within and outside the hot room, with a zero to ground voltage of ≤ 1 V, grounded and a resistance of ≤ 10Ω

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